Andrographolide chigadzirwa chebhotani chakatorwa kubva mugwenzi rinongoitika muChina.Mushonga une nhoroondo yakawanda yekushandiswa muTCM pakurapa kwepamusoro pekufema kwechirwere chetachiona uye zvimwe zvirwere zvinoputika uye zvinotapukira.Andrographis paniculata yakaunzwa uye kurimwa muGuangdong uye kumaodzanyemba kweFujian mu50s.Inoshandiswa kurapa zvirwere zvakasiyana-siyana zvinotapukira uye kurumwa nenyoka.Mumakore achangopfuura, kurima, kuumbwa kwemakemikari, pharmacology uye zvekiriniki zveAndrographis paniculata zvakadzidzwa muChina.Andrographis paniculata mushonga unowanzo shandiswa wechiChinese, une mhedzisiro yekubvisa kupisa nehupfu, kutonhora kweropa uye detumescence.Clinically, rinonyanya kushandiswa pakurapa rekufema turakiti chirwere, acute bacillary dysentery, gastroenteritis, kutonhora, fivha uye hypertension.Nekuwedzera kwekushungurudzwa kwemishonga inorwisa mabhakitiriya uye maitiro akashata, izwi rekugadzira mishonga yechinyakare yeChinese ine yakanaka antibacterial effect iri kukura.Andrographis paniculata, semushonga wechinyakare weChinese une antibacterial effect, yakabhadharwa zvakanyanya neindasitiri yemishonga.
Andrographis paniculata chirimwa chinotorwa chinozivikanwa kuve chine dzakasiyana siyana dzemishonga yemishonga.Andrographolide, iyo huru inoumba iyo inotorwa inobatanidzwa kune yayo pharmacological chiitiko.Isu takadzidza maitiro emasero uye zvinangwa zvakagadziridzwa ne andrographolide kurapwa mugomarara remunhu uye maseru edziviriro.Andrographolide kurapwa kwakadzivisa in vitro kuwanda kweakasiyana tumor cell mitsara, inomiririra akasiyana marudzi egomarara.Mushonga wacho unoshandisa zvakananga anticancer chiitiko pamasero egomarara nekusungwa kwesero-kutenderera paG0/G1 chikamu kuburikidza nekuiswa kwesero-cycle inhibitory protein p27 uye kuderera kwekutaura kwecyclin-inotsamira kinase 4 (CDK4).Immunostimulatory activity ye andrographolide inoratidzwa nekuwedzera kupararira kwe lymphocytes uye kugadzirwa kwe interleukin-2.Andrographolide yakasimbisawo tumor necrosis factor-alpha kugadzirwa uye CD marker kutaura, zvichikonzera kuwedzera cytotoxic chiitiko che lymphocytes kurwisa cancer maseru, ayo anogona kubatsira kune ayo asina kunanga anticancer chiitiko.Iyo in vivo anticancer chiitiko chekomboni inosimbiswa zvakare kurwisa B16F0 melanoma syngenic uye HT-29 xenograft modhi.Mhedzisiro iyi inoratidza kuti andrographolide inonakidza pharmacophore ine anticancer uye immunomodulatory zviitiko uye nekudaro ine mukana wekugadzirwa sekenza yekurapa mumiriri.
Nguva yekutumira: Jun-22-2021
